Takes place in 2029, 2 years after Human Revolution.
Jensen is part of a covert, goverment-sponsored task force called Task Force 29, a new bracnh of Interpol, to combat a new breed of terrorism. In true Deus Ex fashion, you often receive conflicting missions, neither can be fully trusted.
Boss encounters are designed in a way to allow players to approach any way they want (stealth, full combat, etc). "You can go full combat or full stealth throughout any part of the game".
Side quests meant to be more meaningful; ex. players can choose to make deals with criminal organizations and its mob boss might call in a favor later interrupting main missions.
Doesn't want fetch quests, the team sees the extra quests as a way to explore the main themes of the game more deeply.
Features twice as many augmentations as Human Revolution.
Tesla: little darts pop out of Jensen's knuckles allowing him to tag enemies and take them out quietly.
Silent Run: Allows Jensen to move quickly across any floor without making a sound (can combine with cloaking).
C.A.S.I.E.: Allows Jensen to analyze the mental state of individuals, helping him to respond adequately in conversations.
PEPS Gun: Non-lethal weapon that pops out of Jensen's bionic arm and fires a concussive blast allowing him to knock an enemy out, kill him or flee.
Focused on making A.I. more aggressive, flanking, etc.
Certain elements of the environment now react to combat